Consider the naked mole rat. These little pink rodents are similar to mice. But while mice live for about three years, naked mole rats routinely make it to 25. Here we meet physiologist Rochelle Buffenstein PhD — who oversees the largest captive colony of naked mole rats (2,000 of them), tracking them to find the secret to their longevity.
Amos Baruch, Ph.D. Director, Biomarker Development and Translational Medicine Anastasia Baryshnikova, Ph.D. Principal Investigator Bryson Bennett, Ph.D. Principal Investigator and Head of Mass Spectrometry Nick van Bruggen, Ph.D. Distinguished Principal Investigator Rochelle (Shelley) Buffenstein, Ph.D. Senior Principal Investigator Aide Castro Director, Clinical Operations Dan Eaton, Ph.D.
Rochelle Buffenstein, PhD Calico Lab. Carla Daniela Robles-Espinoza, PhD International Laboratory for Human Genome Research. Titia De Lange, PhD Rockefeller University. Roger Greenberg, MD, PhD Univeristy of Pennsylvania. Dirk Hockenmeyer, PhD University of California, Berkeley. Marcin Imielinski, MD, PhD Weill Cornell Medicine. Jan Karlseder, PH.D. The Salk Institute. Joachim Lingner.
We are excited to feature women in science for this year’s annual report, highlighting the important work of grantees Rochelle Buffenstein, PhD, Arti Hurria, MD, and Holly Van Remmen, PhD. Their reseach spans from investigating the mechanisms of neuromuscular aging, to testing the how older adults tolerate cancer therapy drugs, to using long.
Holly M. Brown-Borg, PhD University of North Dakota, Grand Forks, ND The effects of dietary intervention on accelerated aging and age-related disease Rochelle Buffenstein, PhD Calico Labs, South San Francisco, CA Proteostatic mechanisms of the extremely long-lived naked mole rat Vishwa Deep Dixit, PhD Yale University, New Haven, CT.
Adrian J. Lambert, Helen M. Boysen, Julie A. Buckingham, Ting Yang, Andrej Podlutsky, Steven N. Austad, Thomas H. Kunz, Rochelle Buffenstein and Martin D. Brand, Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms, Aging Cell, 6, 5, (607-618), (2007).
The Gerontological Society of America (GSA) — the nation’s largest interdisciplinary organization devoted to the field of aging — has named 61 exemplary professionals as its newest fellows. The status of fellow — the highest class of membership within the Society — is an acknowledgment of outstanding and continuing work in gerontology.
Lifestyle and Eusociality of NMRs Favor Low Extrinsic Mortality. Because many readers of this special issue may be unfamiliar with this unusual rodent, we present a brief review of what is known about NMRs before addressing new and intriguing findings regarding cardiac function (for additional information see reviews) (5,7,8).NMRs belong to the rodent infraorder Hystricognathi, distinguished.
The Institute for Translational Medicine and Therapeutics (ITMAT) supports research at the interface of basic and clinical research focusing on developing new and safer therapeutics. ITMAT includes faculty, basic research space, and the Center for Human Phenomic Science (CHPS), which derives from the integration of the former General Clinical Research Center (GCRC) of both Penn and the.
Rochelle Buffenstein, PhD Calico Labs, South San Francisco, CA Maintenance of glutathione redox status in the naked mole-rat heart under conditions of high oxidative stress Maria E Figueiredo-Pereira, PhD Hunter College (CUNY), New York, NY Prostaglandin J2: A potential target for halting inflammation-induced neurodegeneration Vadim N Gladyshev.